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Factors related to compliance with oral analgesic treatment of inpatients with chronic pain

Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 374-379 doi: 10.1007/s11684-015-0411-1

Abstract: investigated 100 consecutive inpatients with non-cancer chronic pain who were hospitalized to receive oral, 95%CI: 1.03–3.31, P=0.016) were associated with moderate or non-compliance with oralIn conclusion, the low compliance with oral treatment of analgesics was found in Chinese inpatients with

Keywords： chronic pain     inpatient     oral paregoric drugs     compliance    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)Still, no guidelines or consensus focusing on oral drug therapies for BCL is available.drugs for Chinese BCL patients on the basis of the current application status of oral drugs in ChinaThis consensus reviewed the application of oral drugs in the treatment of BCL and the latest researchand provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Although various strategies have been used to study anti-ZIKV agents, approved drugs or vaccines forRepurposing clinically approved drugs could be an effective approach to quickly respond to an emergencyThe well-established safety profiles and optimal dosage of these clinically approved drugs could providefocuses on the recent research and development of agents against ZIKV infection by repurposing clinical drugs

Keywords： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 516-520 doi: 10.1007/s11705-017-1658-7

Abstract: products are formulated with a drug, an active ingredient to produce the maximum therapeutic effect after oralorder to assure the safety and efficacy of pharmaceutical products, we need an predictive tool for oralOral immediate release (IR) dosage forms cannot be optimal for all drugs or likely even any drugs (APIsBut how do we optimize oral delivery of drugs? It is usually through ‘trial and error’, in humans!We need a better way to optimize the oral dosage forms.

Keywords： GIS     in vivo predictive dissolution     ketoconazole     BCS subclassification     supersaturation    

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Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 401-413 doi: 10.1007/s11684-011-0161-7

Abstract: preclinical animal models for bone regeneration and the key translational points to clinical success in oralstrategies based on stem cell and tissue engineering researches, allowing for clinical application in oral

Keywords： bone regeneration     animal models     translational strategies     oral and maxillofacial region    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Frontiers of Medicine doi: 10.1007/s11684-023-1037-3

Abstract: So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivirTo date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approvalThese drugs include azvudine, simnotrelvir–ritonavir (Xiannuoxin), leritrelvir, and mindeudesivir (VV116understanding and highlight the potential widespread application of China’s homegrown anti-COVID-19 drugs

Keywords： COVID-19     antiviral drugs     mindeudesivir    

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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: Oral insulin delivery has received the most attention in insulin formulations due to its high patientHowever, oral insulin delivery has two major limitations: the enzymatic barrier that leads to rapid insulinmajor success in overcoming the mucosal barrier, which is the main cause in undercutting insulin’s oralIn this review of our group’s research, an innovative silica-based, mucoadhesive oral insulin formulationdelivery of many other bioactive compounds, especially for peptide or protein drugs which inevitably

Keywords： insulin     cell penetrating peptide     mucoadhesive composites     oral delivery    

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Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1140-5

Abstract:

We developed a method for determining 11 abused drugs in water and

METH and EPH were the dominant drugs in water

Abuse drugs in Beiyunhe River were mainly from

Abused drugs in the water would not impair the

Keywords： Drugs of abuse     Occurrence     Distribution     Urban river     Environmental risk    

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Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 452-458 doi: 10.1007/s11684-009-0080-z

Abstract: authors performed a meta-analysis of case-control studies that addressed whether reproductive factors and oralmenopausal age >50yr [odds ratio (OR), 1.39; 95% confidence interval (CI), 1.22―1.57] and oralMenopausal age >50yr and oral contraceptive use are positively correlated with an increase

Keywords： meta-analysis     breast cancer     risk factors     reproductive factors     oral contraceptive use    

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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: expression of pituitary tumor transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in oral

Keywords： carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

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A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Engineering doi: 10.1016/j.eng.2023.05.024

Abstract: Thus, DPH endows probiotics with excellent intestine-targeted delivery, improved oral bioavailabilityexhibit almost unchanged bioactivity in the gastrointestinal tract before release, as well as improved oral

Keywords： Polysaccharides     Chitosan     Hydrogels     Oral delivery     Intestine-targeted    

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Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 318-326 doi: 10.15302/J-FASE-2015080

Abstract: The effects of oral administration of garlic mixture (GM, water-soluble extract) on infectious bursalThe results confirmed the protective effects of oral administration of 5 mg·kg BW GM (Group GM1) onsignificantly increased 7 days post infection in bursae in Group GM1 ( <0.01), suggesting that the oral

Keywords： garlic     infectious bursal disease virus (IBDV)     antiviral effect     IgM-bearing B lymphocyte    

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nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: challenges in developing efficient and target specific delivery systems of small molecule and nucleic acid drugs

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 411-417 doi: 10.1007/s11684-013-0293-z

Abstract: telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugsThese results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres

Keywords： telomere     antineoplasic drugs     conventional chemotherapies    

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Title Author Date Type Operation

Factors related to compliance with oral analgesic treatment of inpatients with chronic pain

Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Journal Article

Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Journal Article

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Journal Article

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Journal Article

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Journal Article

Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Journal Article

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Journal Article

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Journal Article

Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Journal Article

nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Journal Article

Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Journal Article

A Review of the International Workshop on “Technological Upgradation of Drugs/Pharmaceutical & Agrochemical

LI Zhengming

Journal Article